Drug-resistant Organisms Essay Example for Free

Drug- disgusting Organisms EssayBy the 1960s, the discovery of antibiotic drugs and subsequent advances in their synthesis led to the conquest of most bacteriuml diseases, at least in developed countries. In the 1969, the Surgeon General of the United States proclaimed that it was time to cultivation the book on infectious diseases (Krasner 29) It indeed seemed so. But today, we confront not lonesome(prenominal) new infectious diseases such as AIDS, but likewise a resurgence of old diseases such as tuberculosis and malaria that were written off rather prematurely over a generation ago. The old diseases be hind end with a vengeance, sporting frightening new faces.The same bacteria that some disappeargond are now resistant to penicillin, ampicillin, erythromycin, vancomycin, fluoroquinolones all the weapons that were supposed to study vanquished them. These bacteria assume evolved and pose tremendous new challenges, however man and mans technology sewer also steadily a dvance to effectively mitigate the emerging bacterial threats only a vast new impetus to research is needed. Not too long ago, people in the Western countries tended to think of deadly infectious diseases as old-fashioned afflictions that belonged to pre-modern times (or to the present-day Third mankind).Since the end of the Second World War, classical sexual diseases like syphilis and gonorrhea virtually disappeared in almost all the industrialized countries (Mode, Sleeman 16). The sexual revolution in the 1970s was encouraged by the confidence that sexually transmitted diseases were merely a temporary vex that penicillin could cure. And then there appeared AIDS. As if that is not enough, practiced when we thought at least our old enemies were gone, to our dismay we find them all staring in our face, much than ferociously than ever. E.coli, staphylococci and many other pathogens are evolving in scary ways. The more researchers investigate, the more fast-changing microbes they find. As a result of this evolution, many bacteria are learning to resist more and more of the antibiotics we humans use to fight them. Drugs that have once so effectively countered many deadly are losing their power. Without the garter of these once magical drugs, regular people who have robust tolerant systems can be seriously sickened or killed by virulent germs, and people with compromised immune systems face a significant chance of dying.A bacteria can mutate any time it reproduces, and all of that bacterias offspring leave bear that mutation. Because bacteria replicate so often, random genetic mutations are common, and some of those mutations create genes that arm bacteria with drug resistor. A change in even just one gene can give a new strain of bacteria the ability to fend off a given antibiotic, maybe even all of the antibiotics in a large class of drugs. Such resistance genes provide bacteria with remarkable defense mechanisms. Resistance can begin in a single soul fulness when bacteria are only partially challenged by medication.This can occur when a patient is given too emit a dosage of a drug, or stops taking it when he feels better, without completing the full course of treatment. Sometime children spit out half of the medicament they are given because of the taste. These conditions allow a pathogen to develop ways to fend off the chemical warriors. Then its descendents mutate in a way that makes them more capable of surviving higher doses of the same drug. Successive generations, which can occur in a matter of days if not hours, possess an ever-growing ability to standard the medication, ultimately creating pathogens that become completely resistant to the drug.Most antibiotics are broad spectrum, meaning they attack any and all bacteria in the patients body. When a person takes an antibiotic for a staph infection, for example, the drug molecules will kill the invaders but also destroy harmless/helpful bacteria, in a situation of relat ed damage. Normally, healthy bacteria occupy most of the places in the stomach and intestines guarding against harmful bacteria percolating into bloodstream. The helpful bacteria also consume a large delegate of nutrients available to bacteria, thus keeping the pathogenic bacteria at bay and keeping us from getting sick more often.But after antibiotics have attacked, they become thinned out, leaving the harmful bacteria which may have randomly mutated and acquired drug resistance to be free, feed and multiply. The healthy bacteria will reestablish themselves, but the drug-resistant pathogens will settle among them in greater numbers. And they will have evolved to better resist the same antibiotic when it comes the next time. Moreover, bacteria also develop new traits by exchanging genes with one another.A staphylococcus bacteria one of the most common pathogens could be handed a new resistance gene by a different kind of resistant bacteria that happens to be close by, or by speci al viruses that infect bacteria and can take genes with them to their next host. Otherwise harmless bacteria inhabiting our gut or skin could become reservoirs of drug-resistance genes, passing them on to visiting pathogens. Most importantly, when an organism becomes resistant to one drug, say penicillin, it is also likely to resist related drugs such as ampicillin and amoxycillin.Finding new molecular structures of this family of drugs cannot provide any semipermanent advantage, because in a few years the organism will become resistant to the whole family again. An entirely new type of drug, or better, a on the whole new approach to combat disease is needed which, in practical terms, translates to massive research on unprecedented levels. Despite several obvious minacious trends for decades now, only three new classes of antibiotics oxazolidinones, streptogramins, and daptomycin have been developed in the past three decades (Galanter et al., 500).This pace of research is compl etely inadequate. We now face a unspoiled crisis situation. The reappearance of TB and the increase in cases of antibiotic-resistant pneumonia and meningitis leave little room for complacency in the search for new drugs, if we are to continue to enjoy our lives that are relatively free of bacterial infections. Man will be successful, as he has been since the observations of Pasteur, in finding or creating new antibiotics if he gives his mind a vast new scope to pursue knowledge and discovery in the new millennium.References Mode, Charles J. , Sleeman, Candace K. Stochastic Processes in Epidemiology HIV/AIDS, Other Infectious Diseases and Computers. Singapore World Scientific Publishing Co. , 2000 Galanter, Joshua Mark Golan, David E. Tashjian, Armen H. Principles of Pharmacology The Pathophysiologic Basis of Drug Therapy Baltimore, MD Lippincott Williams Wilkins, 2005 Krasner, Robert I. The Microbial Challenge Human Microbe Interactions. Washington, DC ASM (American Society for Microbiology) Press, 2002